What is “a simulation box” in LAMMPS and howto get lattice parameters of a solid

Hello,users:

I feel it difficult to understand the characteristics of “a simulation box” in LAMMPS.
I define my simulation box by “read_data” command and the data file comes from the transformation of a CIF file by OVITO software.
Here is the sentences controlling the size of the simulation box in the data file produced by OVITO:

0.0 10.5 xlo xhi
0.0 10.5 ylo yhi
0.0 10.5 zlo zhi


In fact, since this data file comes from a CIF file which contains the information of lattice parameters(a,b,c), the size of simulation box in this data file should perfectly equal the three lattice parameters. But what will happen if i manually change these numbers(e.g. 10.5 becomes 11, 21 or 31.5)
LAMMPS will see the extra volumes produced by this way as vacuum?
I want to study the hydrogen diffusion in the inner of ZrO2 solid.
If so, when I manually rewrite these numbers and make them bigger, will the ZrO2 suprcell no longer consistent when considering the periodic boundary conditions?
Besides, I concern the lattice parameters more than the size of simulation box because I want to calculate thermal expansion coefficient.
But it seems LAMMPS can not directly get the lattice parameters of a crystal.
Is it OK? if I just calculate the lattice parameters from the size of simulation box by a simple division:
that is to say, if the simulation box perfectly contains three ZrO2 unit cell along the x direction of the simulation box. Then the lattice parameters ‘a’ of the ZrO2 unit cell is perfectly equal lx/3 (lx is the size of simulation box along its x direction)
The final problem.
I have noticed the size of simulation box dynamically changed with a NPT thermostat. But why they always have Isotropic variation
key sentences in my ‘in file’ :
fix ensemble2 all npt temp 900 900 10 iso 0 0 100
I guess it is caused by " iso "?
If I want to simulation the anisotropy change of lattice parameters of ZrO2 unit cell, “fix npt temp aniso” is necessary and OK ?

Any advice and instruction will be welcome and appreciated.
Baoshuai

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There isn’t a single LAMMPS specific question here that is not answered by carefully studying the manual and making some experiments and visualizing the results of that. Everything else is not about LAMMPS but about learning how to do research and that is not the job of this forum.